The Veening lab is interested in understanding fundamental processes in the pneumococcus, the main cause of community acquired pneumonia and meningitis in children and the elderly. Using a multidisciplinary approach, including quantitative single cell techniques, systems and synthetic biology, we address how pneumococci grow and divide and segregate their DNA prior to cell division. We are also interested in the role of phenotypic variation for pneumococcal virulence and antibiotic resistance development.
Insights obtained from our research will lead to a better understanding of the biology of Streptococcus pneumoniae and might result in new treatment strategies for pneumococcal infections.
Five exciting papers of the last five years
- Renske van Raaphorst, Kjos M. and Veening J.W. Chromosome segregation drives division site selection in Streptococcus pneumoniae. PNAS. 2017. 14(29): E5959-E5968. Highlighted in Nature Reviews Microbiology.
- We show that Z-ring formation occurs coincidentally with the initiation of DNA replication.
- Xue Liu, Gallay C., Kjos M., Domenech A., Slager J., van Kessel S.P., Knoops K., Sorg R.A., Zhang J.R., Veening J.W. High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae. Mol. Syst. Biol. 2017. 13(5):931.
- Development of an important resource for the pneumococcal community.
- Rieza Aprianto, Slager J., Holsappel S., and Veening J.W. Time-resolved Dual RNA-Seq Reveals Extensive Rewiring of Lung Epithelial and Pneumococcal Transcriptomes during Early Infection. Genome Biology. 2016. 17(1):198.
- New insights on gene regulation of both host and bacteria during infection.
- Robin A. Sorg and Veening J.W. Micro-scale insights into pneumococcal antibiotic mutant selection windows. Nature Communications. 2015 Oct 30; 6:8773. doi: 10.1038/ncomms9773.
- Direct observations of phenotypic variation in antibiotic susceptibility.
- Jelle Slager, Kjos M., Attaiech L. and Veening J.W. Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin. Cell. 2014), 157 (2): 395–406. Featured article, with podcast. Highlighted in Nature Reviews Genetics and Nature Reviews Microbiology.
- The mechanism by which certain antibiotics induce competence is unravelled.